Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.31 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GRM8 | O00222 | 1/20 | 0.31 |
| ▸ | GRM6 | O15303 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2210895 | 0.70 | HSD11B1 (0.34) | HSD11B1SMN1; SMN2 | |
| SCHEMBL12289214 | 0.68 | KMT2A (0.34) | HSD11B1SMN1; SMN2TDP1KDM4E | |
| SCHEMBL2150720 | 0.67 | LMNA (0.37) | SMN1; SMN2CYP2C19LMNATSHR | |
| Cyclopropanecarboxylic Acid Amide SCHEMBL29183025 | 0.66 | KDM4E (0.46) | SMN1; SMN2CYP2C19TDP1LMNATSHR | |
| SCHEMBL31269742 | 0.66 | GPR119 (0.36) | HSD11B1SMN1; SMN2KDM4E | |
| SCHEMBL3543659 | 0.65 | SMN1; SMN2 (0.40) | GRM2GRM3GRM4SMN1; SMN2CYP1A2 | |
| SCHEMBL2209119 | 0.64 | KMT2A (0.34) | SMN1; SMN2TDP1KDM4E | |
| SCHEMBL3734732 | 0.64 | KMT2A (0.39) | HSD11B1SMN1; SMN2TDP1KDM4E | |
| Cyclopropanecarboxylic Acid Amide SCHEMBL8743189 | 0.63 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP2C19TDP1LMNATSHR | |
| SCHEMBL2232346 | 0.63 | SMN1; SMN2 (0.43) | GRM2GRM3GRM4SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121669-A2 | FURANONE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | Biogen Idec MA, Inc. (US) | 2009-11-25 | — | — | EP | claimed |
| WO-2008094574-A2 | FURANONE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. (US) | 2008-08-07 | — | — | WO | claimed |
| EP-2121669-A2 | FURANONE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | Biogen Idec MA, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008094574-A2 | FURANONE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. (US) | 2008-08-07 | — | — | WO | disclosed |