Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 5/20 | 0.45 |
| ▸ | MITF | O75030 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440361 | 0.88 | MEN1 (0.53) | KMT2AMEN1MAPK1L3MBTL1MAPT | |
| SCHEMBL4936269 | 0.78 | FAAH (0.41) | MAPK1L3MBTL1MAPTCNR1NPSR1 | |
| SCHEMBL15807215 | 0.77 | NPSR1 (0.37) | MAPK1L3MBTL1CNR1CNR2NPSR1 | |
| SCHEMBL4428027 | 0.77 | CASR (0.48) | KMT2AMEN1KDM4EPOLBHTT | |
| SCHEMBL22893654 | 0.75 | L3MBTL1 (0.46) | KMT2AMEN1MAPK1L3MBTL1MAPT | |
| SCHEMBL8032599 | 0.75 | MEN1 (0.38) | KMT2AMEN1LMNAALDH1A1CYP2D6 | |
| SCHEMBL23243763 | 0.75 | SLC6A2 (0.41) | KMT2AMEN1MAPK1L3MBTL1MAPT | |
| SCHEMBL23243764 | 0.75 | SLC6A2 (0.41) | KMT2AMEN1MAPK1L3MBTL1MAPT | |
| SCHEMBL23243762 | 0.75 | SLC6A2 (0.41) | KMT2AMEN1MAPK1L3MBTL1MAPT | |
| SCHEMBL29445320 | 0.75 | SLC6A2 (0.41) | KMT2AMEN1MAPK1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |