Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.53 |
| ▸ | FAAH | O00519 | 7/20 | 0.51 |
| ▸ | GHSR | Q92847 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29882799 | 1.00 | MTNR1A (0.53) | MTNR1AMTNR1BFAAHGHSRP2RX7 | |
| SCHEMBL29519648 | 0.87 | KMT2A (0.54) | MTNR1AMTNR1BFAAHKMT2AHSD11B1 | |
| SCHEMBL857083 | 0.87 | KMT2A (0.54) | MTNR1AMTNR1BFAAHKMT2AHSD11B1 | |
| SCHEMBL31330957 | 0.83 | FAAH (0.49) | MTNR1AMTNR1BFAAHGHSRP2RX7 | |
| SCHEMBL12473133 | 0.82 | FAAH (0.63) | FAAH | |
| SCHEMBL10260957 | 0.82 | FAAH (0.57) | FAAH | |
| SCHEMBL30437453 | 0.82 | KDM4E (0.50) | MTNR1AMTNR1BFAAHGHSRKMT2A | |
| SCHEMBL3630406 | 0.82 | KDM4E (0.50) | MTNR1AMTNR1BFAAHGHSRKMT2A | |
| SCHEMBL6819517 | 0.82 | MTNR1A (0.64) | MTNR1AMTNR1B | |
| SCHEMBL8074265 | 0.82 | MTNR1A (0.64) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1069309-C | N-(3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydronaphtalene-2-carboxamide derivative, preparation and application of same | SANNOFFE SYNTHELABO (FR) | 2001-08-08 | — | — | CN | claimed |
| CN-1109870-A | N-(3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydronaphtalene-2-carboxamide derivative, preparation and application of same | SYNTHELABO (FR) | 1995-10-11 | — | — | CN | claimed |
| CN-115197036-B | Method for performing anti-mahalanobis hydrogen carboxylation reaction on photocatalytic olefin compound and carbon dioxide | 中国科学院理化技术研究所 | 2024-01-23 | — | — | CN | disclosed |
| CN-115197036-A | Method for carrying out anti-Ma hydrocarboxylation reaction on olefin compound and carbon dioxide by photocatalysis | 中国科学院理化技术研究所 | 2022-10-18 | — | — | CN | disclosed |
| CN-106687446-B | 5-amino-4-carbamoyl-pyrazole compounds as selective and irreversible kinase inhibitors of T790M/WT-EGFR and uses thereof | 百济神州(北京)生物科技有限公司 | 2020-04-28 | — | — | CN | disclosed |
| CN-104583177-B | Aryl alkyl amines as calcium-sensing receptor regulator | 卢平亚特兰蒂斯控股有限公司 | 2016-09-07 | — | — | CN | disclosed |
| WO-2016008411-A1 | 5-AMINO-4-CARBAMOYL-PYRAZOLE COMPOUNDS AS SELECTIVE AND IRREVERSIBLE T790M OVER WT-EGFR KINASE INHIBITORS AND USE THEREOF | BEIGENE, LTD. (KY) | 2016-01-21 | — | — | WO | disclosed |
| US-9163001-B2 | Substituted chroman compounds as calcium sensing receptor modulators | LUPIN LIMITED (IN) | 2015-10-20 | — | — | US | disclosed |
| US-9163001-B2 | Substituted chroman compounds as calcium sensing receptor modulators | LUPIN LIMITED (IN) | 2015-10-20 | — | — | US | disclosed |
| CN-104583177-A | Arylalkylamine compounds as calcium sensing receptor modulators | LUPIN LTD | 2015-04-29 | — | — | CN | disclosed |
| US-20150038546-A1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2015-02-05 | — | — | US | disclosed |
| EP-0516980-B1 | Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL PHARMA INC (US) | 1996-04-17 | — | — | EP | disclosed |
| CN-1109870-A | N-(3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydronaphtalene-2-carboxamide derivative, preparation and application of same | SYNTHELABO (FR) | 1995-10-11 | — | — | CN | disclosed |
| US-5252601-A | 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-10-12 | — | — | US | disclosed |
| EP-0310745-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | ORION-YHTYMÄ OY (FI) | 1993-01-27 | — | — | EP | disclosed |
| EP-0516980-A1 | Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1992-12-09 | — | — | EP | disclosed |
| EP-0183492-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos-Yhtyma Oy (FI) | 1989-11-15 | — | — | EP | disclosed |
| EP-0310745-A2 | Substituted imidazole derivatives and their preparation and use | ORION-YHTYMÄ OY (FI) | 1989-04-12 | — | — | EP | disclosed |
| US-4689339-A | 4-dihydroinden-2-yl-, 4-tetrahydronaphth-2-yl-, and 4-dihydrobenzofuran-2-ylimidazoles, useful to block α2 -adrenergic receptors | FARMOS YHTYMA OY (FI) | 1987-08-25 | — | — | US | disclosed |
| EP-0183492-A1 | Substituted imidazole derivatives and their preparation and use | Farmos-Yhtyma Oy (FI) | 1986-06-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038546-A1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | CASR, RYR2, CALCR | MTNR1A 135/4885MTNR1B 340/4885FAAH 3844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.