SCHEMBL4432687

SCHEMBL4432687

COC(=O)C(Cc1ccccc1)NC(=O)CN

nearest known ligand 0.71

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ATM Q13315 2/20 0.63
ALDH1A1 P00352 3/20 0.62
THRB P10828 1/20 0.62
CYP2C9 P11712 1/20 0.62
CYP2C19 P33261 1/20 0.62
HSD17B10 Q99714 1/20 0.62
LMNA P02545 2/20 0.62
MEN1 O00255 1/20 0.62
KMT2A Q03164 1/20 0.62
POLB P06746 1/20 0.60
GAA P10253 1/20 0.59
RAB9A P51151 1/20 0.59
GLA P06280 1/20 0.58
HDAC1 Q13547 4/20 0.57
HDAC6 Q9UBN7 4/20 0.57
MDM4 O15151 1/20 0.57
MDM2 Q00987 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4432681 1.00 ATM (0.63) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL11582438 0.94 ALDH1A1 (0.64) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL11582434 0.94 ALDH1A1 (0.64) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL28914294 0.90 ATM (0.60) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL28914295 0.90 ATM (0.60) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL10868030 0.90 ALDH1A1 (0.58) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL10347067 0.90 ALDH1A1 (0.58) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL11022951 0.88 TP53 (0.59) ALDH1A1LMNAMEN1KMT2APOLB
SCHEMBL11155440 0.88 TP53 (0.59) ALDH1A1LMNAMEN1KMT2APOLB
Hydrochloric Acid SCHEMBL11347707 0.88 ALDH1A1 (0.63) ATMALDH1A1THRBCYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240399776-A1 COLOR DEVELOPER, THERMAL RECORDING MATERIAL, AND THERMAL RECORDING LAYER COATING MATERIAL SANKO CO., LTD. (JP) 2024-12-05 US disclosed
EP-4269119-A1 COLOR DEVELOPER, HEAT-SENSITIVE RECORDING MATERIAL, AND COATING MATERIAL FOR HEAT-SENSITIVE RECORDING LAYERS Sanko Co., Ltd. (JP) 2023-11-01 EP disclosed
EP-3342599-B1 HEAT-SENSITIVE RECORDING MATERIAL SANKO CO LTD (JP) 2021-06-16 EP disclosed
US-10086634-B2 Heat-sensitive recording material SANKO CO., LTD. (JP) 2018-10-02 US disclosed
US-20180194151-A1 HEAT-SENSITIVE RECORDING MATERIAL SANKO CO., LTD. (JP) 2018-07-12 US disclosed
EP-3342599-A1 HEAT-SENSITIVE RECORDING MATERIAL Sanko Co., Ltd. (JP) 2018-07-04 EP disclosed
US-20130012485-A1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2013-01-10 US disclosed
CN-102272077-A Fluorination of organic compounds 2011-12-07 CN disclosed
EP-2124913-A1 1-AMINOMETHYL- L- PHENYL- CYCLOHEXANE DERIVATIVES AS DDP-IV INHIBITORS Novartis AG (CH) 2009-12-02 EP disclosed
WO-2008077597-A1 1-AMINOMETHYL- L- PHENYL- CYCLOHEXANE DERIVATIVES AS DDP-IV INHIBITORS NOVARTIS AG (CH) 2008-07-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180194151-A1 HEAT-SENSITIVE RECORDING MATERIAL ASIC1, SCN1A, NPR1 ATM 3527/4885ALDH1A1 1820/4885THRB 2194/4885
US-10086634-B2 Heat-sensitive recording material ASIC1, SCN1A, NPR1 ATM 3143/4885ALDH1A1 1666/4885THRB 2029/4885
US-20130012485-A1 ORGANIC COMPOUNDS DPP4, DPP3, DPP7 ATM 4560/4885ALDH1A1 304/4885THRB 1411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.