Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YEATS4 | O95619 | 1/20 | 0.83 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.83 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.83 |
| ▸ | YEATS2 | Q9ULM3 | 1/20 | 0.83 |
| ▸ | PLD2 | O14939 | 19/20 | 0.62 |
| ▸ | PLD1 | Q13393 | 19/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4446497 | 0.91 | YEATS4 (1.00) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL4444405 | 0.89 | YEATS4 (0.84) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL4996577 | 0.86 | PLD2 (0.66) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL4435658 | 0.86 | YEATS4 (0.63) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL4445884 | 0.79 | YEATS4 (0.58) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL4435617 | 0.79 | YEATS4 (0.66) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL5006614 | 0.79 | YEATS4 (0.69) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL4445732 | 0.79 | YEATS4 (0.63) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL5000609 | 0.78 | YEATS4 (0.68) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL4438759 | 0.78 | YEATS4 (0.67) | YEATS4MLLT3MLLT1KCNH2YEATS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | claimed |
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | claimed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | claimed |
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | disclosed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | SPTLC1, SPTLC2, CPT1A | YEATS4 1467/4885MLLT3 4292/4885MLLT1 1888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.