Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432435 | 0.96 | CNR1 (0.49) | CNR1CNR2CASRSLC6A3HTR1A | |
| SCHEMBL4433145 | 0.86 | CNR1 (0.45) | CNR1CNR2CASRSLC6A3HTR1A | |
| SCHEMBL4434660 | 0.85 | ALOX5 (0.43) | CNR1CNR2SLC6A3HTR6LMNA | |
| SCHEMBL4427996 | 0.85 | ALOX5 (0.43) | CNR1CNR2SLC6A3HTR6LMNA | |
| SCHEMBL4434615 | 0.83 | CNR1 (0.51) | CNR1CNR2CASRSLC6A3HTR1A | |
| SCHEMBL4432784 | 0.83 | CNR1 (0.51) | CNR1CNR2CASRSLC6A3HTR1A | |
| SCHEMBL4433690 | 0.83 | CNR1 (0.51) | CNR1CNR2CASRSLC6A3HTR1A | |
| SCHEMBL4429219 | 0.83 | CNR1 (0.51) | CNR1CNR2CASRSLC6A3HTR1A | |
| SCHEMBL4428140 | 0.80 | CTSA (0.37) | CNR1CNR2CASRCTSA | |
| SCHEMBL4431321 | 0.80 | CTSA (0.37) | CNR1CNR2CASRCTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |