Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434425 | 0.92 | KDM4E (0.39) | KDM4EGAAMCOLN3ALDH1A1TP53 | |
| SCHEMBL4434450 | 0.88 | TACR1 (0.38) | ALDH1A1SLC6A4SLC6A2TACR1MEN1 | |
| SCHEMBL4444516 | 0.88 | MAPK1 (0.40) | ALDH1A1SLC6A4SLC6A2TACR1MEN1 | |
| SCHEMBL4434892 | 0.88 | MCOLN3 (0.35) | KDM4EGAAMCOLN3ALDH1A1TP53 | |
| SCHEMBL4439400 | 0.88 | POLB (0.40) | KDM4EGAAMCOLN3ALDH1A1MEN1 | |
| SCHEMBL4437504 | 0.88 | MAPT (0.45) | ALDH1A1CYP3A4TACR1MEN1KMT2A | |
| SCHEMBL4437157 | 0.88 | HCAR3 (0.39) | KDM4EGAACYP3A4MEN1KMT2A | |
| SCHEMBL4445145 | 0.87 | CYP2C9 (0.41) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4434940 | 0.86 | MEN1 (0.39) | KDM4ETP53MEN1KMT2ACYP2D6 | |
| SCHEMBL4438391 | 0.86 | KMT2A (0.36) | KDM4EALDH1A1TP53TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |