Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428623 | 0.78 | CTSV (0.49) | — | |
| SCHEMBL4521805 | 0.77 | ROCK2 (0.54) | — | |
| SCHEMBL2685893 | 0.75 | CTSS (0.66) | IDO1 | |
| SCHEMBL2685894 | 0.75 | CTSS (0.66) | IDO1 | |
| SCHEMBL2686271 | 0.74 | HDAC8 (0.53) | IDO1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL2686273 | 0.74 | HDAC8 (0.53) | IDO1MEN1KMT2ARAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL2686252 | 0.73 | HDAC8 (0.55) | IDO1MEN1KMT2ARAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL2686253 | 0.73 | HDAC8 (0.55) | IDO1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL3331401 | 0.72 | IDO1 (0.44) | IDO1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL15875954 | 0.71 | IDO1 (0.52) | IDO1MEN1KMT2ARAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134175-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008121786-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-09 | — | — | WO | disclosed |