Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.45 |
| ▸ | GPR142 | Q7Z601 | 4/20 | 0.42 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | PTGIR | P43119 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.40 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4543909 | 0.79 | HDAC8 (0.39) | CTSVCTSLCTSBCTSSHDAC8 | |
| SCHEMBL3336503 | 0.79 | CTSV (0.51) | CTSVCTSLCTSBCTSSHDAC8 | |
| SCHEMBL13300080 | 0.79 | CTSV (0.51) | CTSVCTSLCTSBCTSSHDAC8 | |
| SCHEMBL4435146 | 0.78 | IDO1 (0.45) | — | |
| SCHEMBL3338335 | 0.78 | CTSV (0.46) | CTSVCTSLCTSBCTSSHDAC8 | |
| SCHEMBL13300082 | 0.76 | CTSS (0.47) | CTSVCTSLCTSBCTSSHDAC8 | |
| SCHEMBL4521805 | 0.76 | ROCK2 (0.54) | CTSLCTSBMMP2 | |
| SCHEMBL23213820 | 0.75 | PORCN (0.49) | CTSVCTSLCTSBCTSSPORCN | |
| SCHEMBL4384617 | 0.74 | HDAC8 (0.43) | CTSVCTSLCTSBCTSSHDAC8 | |
| SCHEMBL4554107 | 0.74 | HDAC8 (0.45) | CTSVCTSLCTSBCTSSHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134175-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008121786-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-09 | — | — | WO | disclosed |