Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methandrostenolone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | GUSB | P08236 | 1/20 | 0.65 |
| ▸ | SHBG | P04278 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.60 |
| ▸ | PGR | P06401 | 2/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methandrostenolone SCHEMBL140928 | 1.00 | LMNA (1.00) | LMNAMAPTCYP19A1CYP3A4GUSB | |
| Methandrostenolone SCHEMBL28423591 | 1.00 | LMNA (1.00) | LMNAMAPTCYP19A1CYP3A4GUSB | |
| Methandrostenolone SCHEMBL21177905 | 1.00 | LMNA (1.00) | LMNAMAPTCYP19A1CYP3A4GUSB | |
| Methandrostenolone SCHEMBL4435272 | 1.00 | LMNA (1.00) | LMNAMAPTCYP19A1CYP3A4GUSB | |
| Methandrostenolone SCHEMBL16755284 | 1.00 | LMNA (1.00) | LMNAMAPTCYP19A1CYP3A4GUSB | |
| Methandrostenolone SCHEMBL6395376 | 0.90 | LMNA (0.81) | LMNAMAPTCYP19A1CYP3A4GUSB | |
| SCHEMBL5270893 | 0.90 | LMNA (0.81) | LMNAMAPTCYP19A1CYP3A4ALDH1A1 | |
| SCHEMBL10861103 | 0.90 | LMNA (0.81) | LMNAMAPTCYP19A1CYP3A4ALDH1A1 | |
| SCHEMBL17775770 | 0.87 | LMNA (0.77) | LMNAMAPTCYP19A1CYP3A4 | |
| SCHEMBL27046922 | 0.86 | LMNA (0.75) | LMNAMAPTCYP19A1CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929295-A4 | — | — | 1999-08-18 | — | — | EP | disclosed |
| EP-0929295-A1 | COMBINED PHARMACEUTICAL ESTROGEN-ANDROGEN-PROGESTIN ORAL CONTRACEPTIVE | WAKE FOREST UNIVERSITY (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998001115-A1 | COMBINED PHARMACEUTICAL ESTROGEN-ANDROGEN-PROGESTIN ORAL CONTRACEPTIVE | WAKE FOREST UNIVERSITY (US) | 1998-01-15 | — | — | WO | disclosed |