SCHEMBL4435401

SCHEMBL4435401

COc1c(CO)ccc(I)c1F

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.37
PDE4A P27815 1/20 0.34
PDE4B Q07343 1/20 0.34
PDE4C Q08493 1/20 0.34
PDE4D Q08499 1/20 0.34
MEP1B Q16820 2/20 0.34
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPK1 P28482 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CD274 Q9NZQ7 2/20 0.32
PDCD1LG2 Q9BQ51 1/20 0.32
PDCD1 Q15116 1/20 0.32
MCL1 Q07820 1/20 0.31
CA2 P00918 1/20 0.31
CA4 P22748 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31287985 0.82 MEP1B (0.41) MAPTPDE4APDE4BPDE4CPDE4D
SCHEMBL3839127 0.82 MEP1B (0.32) MEP1B
SCHEMBL27654036 0.82 MEP1B (0.41) MAPTPDE4APDE4BPDE4CPDE4D
SCHEMBL23286528 0.81 CA2 (0.38) MAPTPDE4APDE4BPDE4CPDE4D
SCHEMBL29825611 0.81 CA2 (0.38) MAPTPDE4APDE4BPDE4CPDE4D
SCHEMBL8134900 0.79 MEP1B (0.39) MAPTPDE4APDE4BPDE4CPDE4D
SCHEMBL27471219 0.79 MEP1B (0.43) MAPTPDE4APDE4BPDE4CPDE4D
SCHEMBL3832480 0.75 MEP1B (0.37) MEP1BKDM4EALDH1A1MAPK1SMN1; SMN2
SCHEMBL30259592 0.75 MEP1B (0.37) MEP1BKDM4EALDH1A1MAPK1SMN1; SMN2
SCHEMBL23286532 0.75 IMPDH2 (0.38) MAPTKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2060566-B1 Poly-substituted aryls DOW AGROSCIENCES LLC (US) 2016-06-08 EP claimed
EP-2060566-A1 Poly-substituted aryls Dow AgroSciences LLC (US) 2009-05-20 EP claimed
EP-1973881-A2 6-(POLY-SUBSTITUTED ARYL)-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 2008-10-01 EP claimed
US-20080051596-A1 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2008-02-28 US claimed
US-20070179060-A1 6-(Poly-substituted aryl)-4-aminopicolinates and their use as herbicides CORTEVA AGRISCIENCE LLC 2007-08-02 US claimed
WO-2007082098-A2 6-(POLY-SUBSTITUTED ARYL)-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2007-07-19 WO claimed
EP-2060566-B1 Poly-substituted aryls DOW AGROSCIENCES LLC (US) 2016-06-08 EP disclosed
EP-2060566-A1 Poly-substituted aryls Dow AgroSciences LLC (US) 2009-05-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070179060-A1 6-(Poly-substituted aryl)-4-aminopicolinates and their use as herbicides AAAS, DDT, AADAC MAPT 462/4885PDE4A 2301/4885PDE4B 1711/4885
US-20080051596-A1 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides AAAS, DDT, AADAC MAPT 462/4885PDE4A 2301/4885PDE4B 1711/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.