Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.44 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.44 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.44 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433139 | 0.80 | MAPT (0.57) | MAPTGAAALDH1A1CHRM1HTR2A | |
| Hydrochloric Acid SCHEMBL4441377 | 0.79 | MAPT (0.56) | MAPTGAAALDH1A1CHRM1HTR2A | |
| SCHEMBL4435722 | 0.78 | MAPT (0.62) | MAPTGAAALDH1A1CHRM1HTR2A | |
| SCHEMBL4440594 | 0.77 | MAPT (0.46) | MAPTPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL265079 | 0.75 | RORC (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL16838845 | 0.74 | MRGPRX4 (0.53) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4441801 | 0.74 | MAPT (0.60) | MAPTGAAALDH1A1CHRM1HTR2A | |
| SCHEMBL8827999 | 0.73 | ALDH1A1 (0.63) | MAPTPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL28224487 | 0.73 | TRPV4 (0.46) | ALDH1A1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL4440255 | 0.72 | MAPT (0.59) | MAPTGAAALDH1A1CHRM1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |