Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | FPR2 | P25090 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441801 | 0.86 | MAPT (0.60) | MAPTGAAKMT2AFPR2ALDH1A1 | |
| SCHEMBL8827999 | 0.85 | ALDH1A1 (0.63) | MAPTGAAMEN1POLBKMT2A | |
| Hydrochloric Acid SCHEMBL4440255 | 0.84 | MAPT (0.59) | MAPTGAAKMT2AFPR2ALDH1A1 | |
| SCHEMBL5108766 | 0.83 | MTNR1A (0.58) | MAPTMEN1KMT2AMAOBCHRM1 | |
| SCHEMBL4433139 | 0.83 | MAPT (0.57) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL6687730 | 0.83 | MAPT (0.86) | MAPTGAAKDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4441377 | 0.82 | MAPT (0.56) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL7474018 | 0.80 | KDM4E (0.60) | MAPTKDM4EMEN1POLBMAPK1 | |
| SCHEMBL4441449 | 0.80 | MAPT (0.60) | MAPTGAAKDM4EMEN1POLB | |
| SCHEMBL5709763 | 0.79 | MAPT (0.60) | MAPTGAAKDM4EMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |