Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.48 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14265179 | 0.83 | TPH1 (0.56) | TPH1LMNASMN1; SMN2SLC9A1HTR7 | |
| SCHEMBL27726091 | 0.81 | CYP2A6 (0.51) | SLC9A1HTR7HTR2BSLC9A2 | |
| SCHEMBL4628406 | 0.80 | SCN2A (0.47) | ALDH1A1LMNACES2CES1SMN1; SMN2 | |
| SCHEMBL7765045 | 0.80 | TPH1 (0.53) | TPH1SLC9A1HTR7HTR2B | |
| SCHEMBL8507061 | 0.78 | HTR2B (0.55) | TPH1ALDH1A1LMNACES2CES1 | |
| SCHEMBL7798553 | 0.78 | TPH1 (0.51) | TPH1SLC9A1HTR7HTR2BSLC9A2 | |
| SCHEMBL7778378 | 0.78 | ALDH1A1 (0.50) | ALDH1A1LMNACES2CES1SMN1; SMN2 | |
| SCHEMBL13813415 | 0.78 | PRSS1 (0.52) | CES2CES1SMN1; SMN2SLC9A1HTR7 | |
| SCHEMBL8506397 | 0.78 | HDAC1 (0.50) | TPH1ALDH1A1SLC9A1SLC9A2HTT | |
| SCHEMBL828587 | 0.77 | TPH1 (0.55) | TPH1SLC9A1HTR7HTR2BNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866610-A | Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical as inhibitors of the cellular NA+/H+ exchange or as a diagnostic, and pharmaceutical containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-02-02 | — | — | US | claimed |
| EP-0612723-B1 | Substituted benzoylguanidines, process for their preparation, their use as medicament, as inhibitor of the cellular Na+/H+ exchange or as diagnostic agent and medicament containing them | HOECHST AG (DE) | 1997-08-27 | — | — | EP | claimed |
| EP-0612723-A1 | Substituted benzoylguanidines, process for their preparation, their use as medicament, as inhibitor of the cellular Na+/H+ exchange or as diagnostic agent and medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-08-31 | — | — | EP | claimed |
| EP-1030894-B2 | CONDUCTIVE ORGANIC COATINGS | HENKEL AG & CO KGAA (DE) | 2009-10-28 | — | — | EP | disclosed |
| JP-2004189755-A | SUBSTITUTED BENZOYLGUANIDINE AND METHOD FOR PRODUCING THE SAME | HOECHST AG | 2004-07-08 | — | — | JP | disclosed |
| EP-1030894-B1 | CONDUCTIVE ORGANIC COATINGS | HENKEL KGAA (DE) | 2003-07-02 | — | — | EP | disclosed |
| US-5866610-A | Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical as inhibitors of the cellular NA+/H+ exchange or as a diagnostic, and pharmaceutical containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-02-02 | — | — | US | disclosed |
| US-5866610-A | Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical as inhibitors of the cellular NA+/H+ exchange or as a diagnostic, and pharmaceutical containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-02-02 | — | — | US | disclosed |
| EP-0612723-B1 | Substituted benzoylguanidines, process for their preparation, their use as medicament, as inhibitor of the cellular Na+/H+ exchange or as diagnostic agent and medicament containing them | HOECHST AG (DE) | 1997-08-27 | — | — | EP | disclosed |
| EP-0612723-A1 | Substituted benzoylguanidines, process for their preparation, their use as medicament, as inhibitor of the cellular Na+/H+ exchange or as diagnostic agent and medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-08-31 | — | — | EP | disclosed |
| EP-0612723-A1 | Substituted benzoylguanidines, process for their preparation, their use as medicament, as inhibitor of the cellular Na+/H+ exchange or as diagnostic agent and medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-08-31 | — | — | EP | disclosed |