Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.50 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | ACR | P10323 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
| ▸ | TPH1 | P17752 | 1/20 | 0.47 |
| ▸ | ESRRG | P62508 | 1/20 | 0.46 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.45 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8506609 | 0.98 | HDAC1 (0.48) | HDAC1SLC22A2SLC22A1SLC22A3PRSS1 | |
| Hydrochloric Acid SCHEMBL8341387 | 0.84 | TPH1 (0.44) | TPH1SLC9A1SLC9A2 | |
| SCHEMBL8168281 | 0.81 | SLC9A1 (0.42) | SLC9A1SLC9A2 | |
| SCHEMBL5690957 | 0.79 | HDAC1 (0.57) | HDAC1SRD5A2ESRRGEPHX2NR1H4 | |
| Hydrochloric Acid SCHEMBL8505496 | 0.79 | HTR2B (0.41) | SLC9A1SLC9A2 | |
| Hydrochloric Acid SCHEMBL8505964 | 0.79 | CES2 (0.53) | PRSS1ACRSRD5A2TPH1SLC9A1 | |
| SCHEMBL4435595 | 0.78 | TPH1 (0.51) | TPH1SLC9A1SLC9A2MEN1ALDH1A1 | |
| SCHEMBL14265179 | 0.78 | TPH1 (0.56) | TPH1SLC9A1SLC9A2KMT2ANPC1 | |
| SCHEMBL284242 | 0.77 | EPHX2 (0.66) | HDAC1SRD5A2TNFKLF5NOD1 | |
| SCHEMBL14879101 | 0.76 | HDAC1 (0.53) | HDAC1SRD5A2ESRRGEPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866610-A | Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical as inhibitors of the cellular NA+/H+ exchange or as a diagnostic, and pharmaceutical containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-02-02 | — | — | US | disclosed |