Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ARG1 | P05089 | 1/20 | 0.33 |
| ▸ | ARG2 | P78540 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6211749 | 0.78 | HRH3 (0.40) | HRH3SLC6A2SLC6A4SLC6A3HSD11B1 | |
| SCHEMBL17274417 | 0.74 | HRH3 (0.37) | HRH3SLC6A2SLC6A4SLC6A3CYP3A4 | |
| SCHEMBL414249 | 0.72 | SLC6A2 (0.56) | HRH3SLC6A2SLC6A4SLC6A3ARG1 | |
| SCHEMBL10956783 | 0.72 | SLC6A2 (0.56) | HRH3SLC6A2SLC6A4SLC6A3ARG1 | |
| SCHEMBL440476 | 0.72 | SLC6A2 (0.56) | HRH3SLC6A2SLC6A4SLC6A3ARG1 | |
| Hydrochloric Acid SCHEMBL7375378 | 0.71 | SLC6A2 (0.55) | HRH3SLC6A2SLC6A4SLC6A3ARG1 | |
| SCHEMBL8083651 | 0.71 | SLC6A2 (0.52) | HRH3SLC6A2SLC6A4SLC6A3ARG1 | |
| SCHEMBL7455945 | 0.71 | SLC6A2 (0.52) | HRH3SLC6A2SLC6A4SLC6A3ARG1 | |
| SCHEMBL11184730 | 0.68 | HRH3 (0.36) | HRH3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6830859 | 0.67 | LMNA (0.40) | HRH3SLC6A2SLC6A4SLC6A3HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134693-A2 | METALLOPROTEASE INHIBITORS CONTAINING A HETEROCYCLIC MOIETY | Alantos Pharmaceuticals Holding, Inc. (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008109181-A2 | METALLOPROTEASE INHIBITORS CONTAINING A HETEROCYCLIC MOIETY | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2008-09-12 | — | — | WO | disclosed |