Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5004185 | 0.89 | PLD1 (0.38) | OPRM1OPRL1OPRK1HTR2AHTR7 | |
| SCHEMBL4435630 | 0.89 | PLD1 (0.36) | OPRM1OPRL1OPRK1HTR2AHTR7 | |
| SCHEMBL4444437 | 0.89 | PLD1 (0.38) | OPRM1OPRL1OPRK1HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL4436906 | 0.88 | PLD1 (0.38) | OPRM1OPRL1OPRK1HTR2AHTR7 | |
| SCHEMBL4439004 | 0.87 | PLD1 (0.38) | OPRM1OPRL1OPRK1HTR2AHTR7 | |
| SCHEMBL4440120 | 0.83 | OPRM1 (0.42) | OPRM1OPRL1OPRK1HTR2AHTR7 | |
| SCHEMBL4444801 | 0.77 | OPRM1 (0.42) | OPRM1PLD1KCNH2CHRM4 | |
| SCHEMBL5000730 | 0.77 | CHRM4 (0.39) | OPRM1OPRL1OPRK1HTR2AHTR7 | |
| SCHEMBL5000753 | 0.76 | OPRL1 (0.45) | OPRM1OPRL1OPRK1PLD1KCNH2 | |
| SCHEMBL14146291 | 0.76 | PLD1 (0.39) | OPRM1OPRL1OPRK1HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | claimed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | claimed |