Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433059 | 0.90 | PLD1 (0.38) | CHRM4KCNH2PLD1CHRM1CHRM2 | |
| Hydrochloric Acid SCHEMBL4440163 | 0.89 | PLD1 (0.38) | CHRM4KCNH2PLD1CHRM1CHRM2 | |
| SCHEMBL5000752 | 0.85 | PLD1 (0.39) | CHRM4KCNH2PLD1CHRM1CHRM2 | |
| SCHEMBL4437442 | 0.83 | PLD1 (0.38) | CHRM4KCNH2PLD1CHRM1CHRM2 | |
| SCHEMBL4439121 | 0.82 | CHRM4 (0.37) | CHRM4KCNH2PLD1CHRM1CHRM2 | |
| SCHEMBL14146291 | 0.79 | PLD1 (0.39) | KCNH2PLD1HTR2AHTR7OPRM1 | |
| SCHEMBL4435781 | 0.77 | PLD1 (0.42) | CHRM4KCNH2PLD1CHRM1CHRM2 | |
| SCHEMBL4446730 | 0.77 | PLD1 (0.43) | CHRM4KCNH2PLD1HTR2AHTR7 | |
| SCHEMBL4435819 | 0.77 | OPRM1 (0.36) | CHRM4KCNH2PLD1HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL4436857 | 0.76 | PLD1 (0.42) | CHRM4KCNH2PLD1HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | claimed |
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | SPTLC1, SPTLC2, CPT1A | CHRM4 4343/4885KCNH2 4650/4885PLD1 351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.