Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10217175 | 1.00 | THRB (0.48) | THRBALDH1A1GAAL3MBTL1SMN1; SMN2 | |
| SCHEMBL10217178 | 0.89 | PNMT (0.47) | ALDH1A1SMN1; SMN2POLBKMT2APNMT | |
| SCHEMBL4447858 | 0.86 | PNMT (0.51) | THRBALDH1A1GAAL3MBTL1SMN1; SMN2 | |
| SCHEMBL382192 | 0.84 | PNMT (0.50) | ALDH1A1SMN1; SMN2POLBKMT2APNMT | |
| SCHEMBL30411420 | 0.84 | PNMT (0.47) | ALDH1A1L3MBTL1SMN1; SMN2ATMPOLB | |
| SCHEMBL20764665 | 0.84 | PNMT (0.47) | ALDH1A1L3MBTL1SMN1; SMN2ATMPOLB | |
| SCHEMBL19265132 | 0.83 | THRB (0.47) | THRBALDH1A1GAAL3MBTL1SMN1; SMN2 | |
| SCHEMBL10216749 | 0.83 | PNMT (0.49) | ALDH1A1L3MBTL1SMN1; SMN2ATMPOLB | |
| Hydrochloric Acid SCHEMBL381834 | 0.83 | PNMT (0.49) | ALDH1A1SMN1; SMN2POLBKMT2APNMT | |
| SCHEMBL10217182 | 0.82 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2POLBKMT2APNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121598-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008076754-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2008-06-26 | — | — | WO | disclosed |