Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SLC18A2 | Q05940 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FPR1 | P21462 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436580 | 1.00 | MAPT (0.44) | MAPTPKMSLC18A2HTR2ASLC6A3 | |
| SCHEMBL4436586 | 1.00 | MAPT (0.44) | MAPTPKMSLC18A2HTR2ASLC6A3 | |
| SCHEMBL8343491 | 1.00 | MAPT (0.44) | MAPTPKMSLC18A2HTR2ASLC6A3 | |
| SCHEMBL6693183 | 1.00 | MAPT (0.44) | MAPTPKMSLC18A2HTR2ASLC6A3 | |
| SCHEMBL6688197 | 0.90 | MAPT (0.40) | MAPTPKMSLC18A2HTR2ASLC6A3 | |
| SCHEMBL6688180 | 0.90 | MAPT (0.40) | MAPTPKMSLC18A2HTR2ASLC6A3 | |
| SCHEMBL6688175 | 0.90 | MAPT (0.40) | MAPTPKMSLC18A2HTR2ASLC6A3 | |
| SCHEMBL6688177 | 0.90 | MAPT (0.40) | MAPTPKMSLC18A2HTR2ASLC6A3 | |
| SCHEMBL6691364 | 0.88 | PDE4A (0.42) | SLC18A2HTR2ASLC6A3PDE4APDE4B | |
| SCHEMBL6691356 | 0.88 | PDE4A (0.42) | SLC18A2HTR2ASLC6A3PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812827-B1 | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation | SUMITOMO CHEMICAL CO (JP) | 2009-09-02 | — | — | EP | disclosed |
| US-6815548-B2 | MINTERMEDIATE FOR PHARMACEUTICALS SUCH AS PAROXETINE USEFUL AS ANTIDEPRESSANTS, REPRESENTED BY THE GENERAL FORMULA (I): | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2004-11-09 | — | — | US | disclosed |
| EP-1394160-A1 | Process for preparing crystalline paroxetin hydrochloride | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2004-03-03 | — | — | EP | disclosed |
| EP-1384720-A1 | Process for drying paroxetine hydrochloride | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2004-01-28 | — | — | EP | disclosed |
| EP-1384711-A1 | Optical resolution of a piperidine derivative | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2004-01-28 | — | — | EP | disclosed |
| US-6610851-B1 | 1-tert-butoxycarbonyl-4-(4-fluorophenyl)-3-((3,4-methylene dioxyphenyl)oxymethyl)piperidine; reacting 4-(4-fluorophenyl)-3-hydroxymethylpiperidine with di-tert-butyl dicarbonate to form the carbamate; 3,4-methylenedioxyphenol | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2003-08-26 | — | — | US | disclosed |
| US-20030144519-A1 | Process for preparing a piperidine derivative | SUMIKA FINE CHEMICALS CO., LTD. | 2003-07-31 | — | — | US | disclosed |
| US-6590102-B1 | Hydrogenation of 2-cyano-3-(p-fluorophenyl)glutaric acid diethyl ester in the presence of catalysts to prepare isomer mixtures of ethyl 4-(p-fluorophenyl)-6-oxo-3-piperidine -carboxylate, used as intermediates of paroxetine | ASAHI GLASS COMPANY LTD. (JP) | 2003-07-08 | — | — | US | disclosed |
| US-6476227-B1 | Piperidine derivative and process for preparing the same | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| US-6476228-B1 | Process for producing piperidinecarbinols | ASAHI GLASS COMPANY LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| US-20010053862-A1 | Process for preparing arylpiperidine carbinol intermediates and derivatives | PENTECH PHARMACEUTICALS, INC. | 2001-12-20 | — | — | US | disclosed |
| EP-0802185-B1 | Process for producing piperidinecarbinols | ASAHI GLASS CO LTD (JP) | 2001-10-17 | — | — | EP | disclosed |
| US-6197960-B1 | REDUCTION OF CYANOGLUTARIC ACID; CYCLIZATION, ISOMERIZATION | ASAHI GLASS COMPANY LTD. (JP) | 2001-03-06 | — | — | US | disclosed |
| US-5948914-A | PREPARING 4-(4-FLUOROPHENYL)-3-HYDROXYMETHYLPIPERIDINE BY OPTICALLY RESOLVING WITH O-CHLOROTARTRANILIC ACID; CHEMICAL INTERMEDIATE FOR DRUGS | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0812827-A1 | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 1997-12-17 | — | — | EP | disclosed |
| EP-0802185-A1 | Process for producing piperidinecarbinols | ASAHI GLASS COMPANY LTD. (JP) | 1997-10-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010053862-A1 | Process for preparing arylpiperidine carbinol intermediates and derivatives | ADH1C, CBR1, MAL2 | MAPT 4854/4885PKM 1172/4885SLC18A2 3615/4885 |
| US-20030144519-A1 | Process for preparing a piperidine derivative | TPH1, TPH2, HTR7 | MAPT 3264/4885PKM 303/4885SLC18A2 536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.