Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434210 | 0.82 | HTR6 (0.44) | HTR6KDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL5670227 | 0.73 | MAP2 (0.40) | HPGDSIRT1KDM4EALDH1A1POLB | |
| SCHEMBL2734801 | 0.67 | NR4A2 (0.40) | HPGDKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL7502576 | 0.66 | HTR6 (0.50) | HTR6KDM4EALDH1A1PABPC1ALOX15 | |
| SCHEMBL2838884 | 0.66 | HTR2A (0.32) | HTR2A | |
| SCHEMBL3482936 | 0.64 | ALDH1A1 (0.48) | HPGDKDM4EALDH1A1POLBHSD17B10 | |
| SCHEMBL6430294 | 0.63 | ALDH1A1 (0.57) | HTR6HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL4619353 | 0.63 | KDM4E (0.58) | HTR6HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL15428085 | 0.62 | ALDH1A1 (0.73) | HPGDKDM4EALDH1A1POLBMDM2 | |
| SCHEMBL15428075 | 0.62 | KDM4E (0.81) | HPGDKDM4EALDH1A1POLBMDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125721-A1 | ARYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008092666-A1 | ARYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-08-07 | — | — | WO | disclosed |