Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.44 |
| ▸ | MAP2 | P11137 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436661 | 0.82 | HTR6 (0.34) | HTR6MAP2CYP1A2HTR1DHTR7 | |
| SCHEMBL5495499 | 0.79 | HTR6 (0.66) | HTR6MAP2HTR1DHTR7KDM4E | |
| SCHEMBL5670227 | 0.76 | MAP2 (0.40) | MAP2HSD17B10KDM4EALDH1A1MEN1 | |
| SCHEMBL4292563 | 0.75 | HTR6 (0.62) | HTR6MAP2CYP1A2HTR1DHTR7 | |
| SCHEMBL28746390 | 0.68 | MCL1 (0.57) | HTR6MAP2HTR1DHTR7KDM4E | |
| SCHEMBL2003146 | 0.67 | KDM4E (0.72) | HTR6KDM4EALDH1A1FOLH1MCL1 | |
| SCHEMBL2734801 | 0.67 | NR4A2 (0.40) | CYP1A2HSD17B10KDM4EALDH1A1CYP3A4 | |
| SCHEMBL3320873 | 0.67 | MCL1 (0.32) | TSHRMCL1 | |
| SCHEMBL5279031 | 0.66 | MAP2 (0.57) | HTR6MAP2KDM4EALDH1A1FOLH1 | |
| SCHEMBL3482936 | 0.66 | ALDH1A1 (0.48) | CYP1A2HSD17B10KDM4EALDH1A1FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125721-A1 | ARYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008092666-A1 | ARYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-08-07 | — | — | WO | disclosed |