Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 2/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | HTR1F | P30939 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | MAP2 | P11137 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CTSV | O60911 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28746390 | 0.93 | MCL1 (0.57) | ALDH1A1KDM4EHTR6MCL1HTR1A | |
| SCHEMBL3881052 | 0.87 | MCL1 (0.67) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL2362152 | 0.86 | KDM4E (0.53) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL5495499 | 0.82 | HTR6 (0.66) | ALDH1A1KDM4EGAAHTR6MCL1 | |
| SCHEMBL9040659 | 0.80 | SIRT1 (0.69) | ALDH1A1KDM4EHPGDHSD17B10MAP2 | |
| SCHEMBL5279031 | 0.79 | MAP2 (0.57) | ALDH1A1KDM4EHPGDGAAHTR6 | |
| SCHEMBL3232433 | 0.78 | SIRT1 (0.56) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL27743122 | 0.77 | KDM4E (0.56) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL2362148 | 0.77 | MAP2 (0.46) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL7502576 | 0.77 | HTR6 (0.50) | ALDH1A1KDM4EHTR6MCL1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040111-A2 | COMBINATORIAL LIBRARY OF 3-ARYL-1H-INDOLE-2-CARBOXYLIC ACIDS | F. HOFFMANN-LA ROCHE AG (DE) | 2005-05-06 | — | — | WO | disclosed |
| US-20050089936-A1 | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides | CAI JIANPING (US) | 2005-04-28 | — | — | US | disclosed |
| US-20050089936-A1 | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides | CAI JIANPING (US) | 2005-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050089936-A1 | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides | AADAC, KYNU, AANAT | ALDH1A1 104/4885KDM4E 2933/4885HPGD 1752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.