Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4444087 | 1.00 | KMT2A (0.38) | KMT2AMEN1HTTCYP1A2CYP3A4 | |
| SCHEMBL4447058 | 0.94 | MAPT (0.36) | KMT2AMEN1HTTCYP1A2CYP3A4 | |
| SCHEMBL4439973 | 0.82 | PBRM1 (0.44) | KMT2AMEN1HTTCYP1A2CYP3A4 | |
| SCHEMBL4440072 | 0.79 | LMNA (0.39) | KMT2AMEN1HTTNTSR1GUSB | |
| SCHEMBL4435442 | 0.78 | DRD2 (0.35) | KMT2ACYP2D6MAPK1DRD2MAPT | |
| SCHEMBL3589802 | 0.78 | MEN1 (0.39) | KMT2AMEN1HTTCYP1A2CYP3A4 | |
| SCHEMBL4436764 | 0.78 | MEN1 (0.39) | KMT2AMEN1HTTCYP1A2CYP3A4 | |
| SCHEMBL3589798 | 0.78 | MEN1 (0.39) | KMT2AMEN1HTTCYP1A2CYP3A4 | |
| SCHEMBL3589801 | 0.78 | MEN1 (0.39) | KMT2AMEN1HTTCYP1A2CYP3A4 | |
| SCHEMBL4444360 | 0.78 | LMNA (0.40) | KMT2AMEN1HTTNTSR1GUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121598-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008076754-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2008-06-26 | — | — | WO | disclosed |