Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | MOGAT2 | Q3SYC2 | 2/20 | 0.43 |
| ▸ | ACACB | O00763 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3182393 | 0.86 | GPR119 (0.58) | HRH3ESR1ESR2ACACBGPR119 | |
| SCHEMBL4563873 | 0.85 | MOGAT2 (0.54) | ESR1ESR2MOGAT2 | |
| SCHEMBL4437579 | 0.83 | ESR1 (0.49) | HRH3ESR1ESR2MOGAT2ACACB | |
| SCHEMBL3176556 | 0.83 | GPR119 (0.54) | HRH3GPR119 | |
| SCHEMBL3178450 | 0.82 | HRH3 (0.55) | HRH3ESR1ESR2MOGAT2 | |
| SCHEMBL3180488 | 0.82 | HRH3 (0.53) | HRH3ESR1ESR2MOGAT2ACACB | |
| SCHEMBL4434244 | 0.81 | HRH3 (0.53) | HRH3ESR1ESR2MOGAT2ACACB | |
| SCHEMBL4434575 | 0.81 | ESR1 (0.42) | HRH3ESR1ESR2MOGAT2ACACB | |
| SCHEMBL4435108 | 0.80 | S1PR5 (0.44) | HRH3ACACBGPR119 | |
| SCHEMBL4437654 | 0.80 | MCHR1 (0.49) | ESR1ESR2MOGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114890-A2 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2009-11-11 | — | — | EP | claimed |
| WO-2008097428-A2 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2008-08-14 | — | — | WO | claimed |