SCHEMBL4437609

SCHEMBL4437609

CCOC(=O)c1csc(C2CCN(C(=O)OCC(C)C)CC2)n1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.48
TSHR P16473 3/20 0.48
GAA P10253 2/20 0.48
HTT P42858 1/20 0.48
HSD17B10 Q99714 1/20 0.48
PPARG P37231 1/20 0.45
CASP3 P42574 1/20 0.44
CASP7 P55210 1/20 0.44
CASP8 Q14790 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.43
MAPT P10636 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
MEN1 O00255 1/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
KMT2A Q03164 1/20 0.43
BRD4 O60885 2/20 0.40
TLR9 Q9NR96 1/20 0.40
TLR8 Q9NR97 1/20 0.40
TLR7 Q9NYK1 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1884146 0.84 CASP3 (0.48) ALDH1A1TSHRGAAHTTHSD17B10
SCHEMBL419527 0.84 GPR119 (0.49) ALDH1A1TSHRGAAHTTHSD17B10
SCHEMBL2973357 0.83 CASP3 (0.47) ALDH1A1TSHRGAAHTTHSD17B10
SCHEMBL2773331 0.83 CASP3 (0.47) ALDH1A1TSHRGAAHTTHSD17B10
SCHEMBL15127746 0.83 ALDH1A1 (0.46) ALDH1A1TSHRGAAHTTHSD17B10
SCHEMBL3594917 0.82 SMN1; SMN2 (0.51) ALDH1A1TSHRGAAHTTHSD17B10
SCHEMBL2774105 0.82 RAB9A (0.50) ALDH1A1TSHRGAAHTTHSD17B10
SCHEMBL2142237 0.81 RAB9A (0.57) ALDH1A1GAACASP3CASP7CASP8
SCHEMBL23384839 0.81 CASP3 (0.49) ALDH1A1TSHRGAAHTTHSD17B10
SCHEMBL5802188 0.81 NR1H2 (0.47) ALDH1A1TSHRGAAHTTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2121660-A2 FUNGICIDAL AMIDES E. I. Du Pont de Nemours and Company (US) 2009-11-25 EP disclosed
WO-2008091580-A2 FUNGICIDAL AMIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-07-31 WO disclosed