Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 4/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 9/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2008360 | 0.93 | NR3C1 (0.35) | CYP11B2CYP11B1GRM1CYP17A1CYP1A2 | |
| SCHEMBL2003406 | 0.93 | CYP11B1 (0.38) | CYP11B2CYP11B1GRM1CYP17A1CYP1A2 | |
| SCHEMBL4447721 | 0.85 | MAPT (0.35) | CYP11B2CYP11B1GRM1CYP17A1CYP1A2 | |
| SCHEMBL2006894 | 0.79 | NR3C1 (0.38) | CYP11B2CYP11B1CYP17A1CYP1A2NR3C1 | |
| SCHEMBL2005767 | 0.77 | ESRRA (0.36) | CYP11B2CYP11B1GRM1NR3C1 | |
| SCHEMBL2004925 | 0.77 | ESR1 (0.37) | CYP11B2CYP11B1NR3C1 | |
| SCHEMBL2009185 | 0.77 | CYP11B1 (0.39) | CYP11B2CYP11B1NR3C1 | |
| SCHEMBL2006268 | 0.77 | TRPA1 (0.35) | CYP11B2CYP11B1NR3C1 | |
| SCHEMBL12572492 | 0.74 | ESR1 (0.33) | CYP11B2CYP11B1NR3C1 | |
| SCHEMBL2002221 | 0.74 | PGR (0.40) | CYP11B2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118068-A1 | INDAZOLES USED TO TREAT ESTROGEN RECEPTOR BETA MEDIATED DISORDERS | Glaxo Group Limited (GB) | 2009-11-18 | — | — | EP | claimed |
| WO-2008107455-A1 | INDAZOLES USED TO TREAT ESTROGEN RECEPTOR BETA MEDIATED DISORDERS | GLAXO GROUP LIMITED (GB) | 2008-09-12 | — | — | WO | claimed |