Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.36 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3887651 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2THRBL3MBTL1MAPTPOLB | |
| SCHEMBL1645322 | 0.83 | SMN1; SMN2 (0.68) | SMN1; SMN2THRBL3MBTL1MAPTPOLB | |
| SCHEMBL4434623 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2THRBL3MBTL1MAPTPOLB | |
| SCHEMBL1645232 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2THRBL3MBTL1MAPTPOLB | |
| SCHEMBL7172307 | 0.75 | MAPT (0.41) | SMN1; SMN2L3MBTL1MAPTPOLBNPSR1 | |
| SCHEMBL6218928 | 0.74 | THRB (0.41) | SMN1; SMN2THRBL3MBTL1MAPTPOLB | |
| SCHEMBL4432353 | 0.74 | SMN1; SMN2 (0.44) | SMN1; SMN2THRBL3MBTL1MAPTPOLB | |
| SCHEMBL29697806 | 0.74 | MMP1 (0.41) | SMN1; SMN2THRBALDH1A1KDM4EHDAC7 | |
| Hydrochloric Acid SCHEMBL6216306 | 0.74 | THRB (0.40) | SMN1; SMN2THRBL3MBTL1MAPTPOLB | |
| SCHEMBL11078528 | 0.73 | NPC1 (0.46) | SMN1; SMN2THRBL3MBTL1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097413-A1 | 2-[(2-SUBSTITUTED)-IND0LIZIN-3-YL]-2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS | F2G Limited (GB) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008062182-A1 | 2- [ (2-SUBSTITUTED) -IND0LIZIN-3-YL] -2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS | F2G LTD (GB) | 2008-05-29 | — | — | WO | disclosed |