Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 1/20 | 0.49 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 6/20 | 0.46 |
| ▸ | KDM4A | O75164 | 5/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | KDM6B | O15054 | 4/20 | 0.44 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.44 |
| ▸ | HIF1AN | Q9NWT6 | 4/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | KDM3B | Q7LBC6 | 3/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428237 | 0.92 | KDM4E (0.50) | HNF4AKDM4EKDM5BKDM4AKDM5A | |
| SCHEMBL3912930 | 0.92 | KDM4E (0.53) | HNF4AKDM4EKDM5BKDM4AKDM5A | |
| SCHEMBL4430692 | 0.89 | KDM4E (0.51) | HNF4AACMSDKDM4EKDM5BKDM4A | |
| SCHEMBL4438787 | 0.86 | KDM4E (0.41) | HNF4AACMSDKDM4EKDM5BKDM4A | |
| SCHEMBL4438623 | 0.86 | HCAR2 (0.54) | KDM4EHCAR2DAO | |
| SCHEMBL4431491 | 0.86 | HCAR2 (0.54) | KDM4EKDM5BKDM4AKDM5AKDM4C | |
| SCHEMBL4380912 | 0.86 | HCAR2 (0.54) | KDM4EKDM5BKDM4AKDM4CHCAR2 | |
| SCHEMBL4438837 | 0.85 | ALDH1A1 (0.49) | KDM4EPARP1DAOMPORNASEH1 | |
| SCHEMBL4431596 | 0.84 | KDM4E (0.45) | HNF4AKDM4EHCAR2DAO | |
| SCHEMBL4432530 | 0.84 | KDM4E (0.47) | HNF4AKDM4EKDM5BKDM4AKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |