Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29771048 | 1.00 | CA2 (0.54) | CA2CYP1A2CYP3A4CYP2C19CYP2A6 | |
| SCHEMBL29239834 | 0.80 | CA2 (0.57) | CA2CYP1A2CYP3A4CYP2C19CYP2A6 | |
| SCHEMBL8694638 | 0.78 | CA2 (0.56) | CA2CYP1A2CYP3A4CYP2C19CYP2A6 | |
| SCHEMBL144455 | 0.78 | CA2 (0.56) | CA2CYP1A2CYP3A4CYP2C19CYP2A6 | |
| SCHEMBL12675254 | 0.77 | CA2 (0.54) | CA2CYP1A2CYP3A4CYP2C19CYP2A6 | |
| SCHEMBL8602480 | 0.77 | CA2 (0.54) | CA2CYP1A2CYP3A4CYP2C19CYP2A6 | |
| SCHEMBL5542989 | 0.77 | CA2 (0.54) | CA2CYP1A2CYP3A4CYP2C19CYP2A6 | |
| SCHEMBL1107212 | 0.77 | BACE1 (0.73) | CA2CYP1A2CYP3A4CYP2C19CYP2A6 | |
| SCHEMBL205800 | 0.76 | HDAC6 (0.48) | CA2MAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL5243924 | 0.74 | CA2 (0.51) | CA2CYP1A2CYP3A4CYP2C19CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12018019-B2 | Estrogen receptor-modulating compounds | RADIUS PHARMACEUTICALS, INC. (US) | 2024-06-25 | — | — | US | disclosed |
| US-10604506-B2 | Modulators of estrogen receptor proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2020-03-31 | — | — | US | disclosed |
| US-20090286863-A1 | SULFAMATOBENZOTHIOPHENE DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 2009-11-19 | — | — | US | disclosed |
| US-20090286863-A1 | SULFAMATOBENZOTHIOPHENE DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 2009-11-19 | — | — | US | disclosed |
| US-7476691-B2 | Sulfamate benzothiophene derivatives as steroid sulfatase inhibitors | LABORATOIRE THERAMEX (MC) | 2009-01-13 | — | — | US | disclosed |
| US-7476691-B2 | Sulfamate benzothiophene derivatives as steroid sulfatase inhibitors | LABORATOIRE THERAMEX (MC) | 2009-01-13 | — | — | US | disclosed |
| WO-2008003378-A1 | SULFAMATE BENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10604506-B2 | Modulators of estrogen receptor proteolysis and associated methods of use | ADRM1, MDM2, ESR2 | CA2 3519/4885CYP1A2 3656/4885CYP3A4 4408/4885 |
| US-12018019-B2 | Estrogen receptor-modulating compounds | ESR2, GPER1, ESR1 | CA2 2407/4885CYP1A2 718/4885CYP3A4 977/4885 |
| US-20090286863-A1 | SULFAMATOBENZOTHIOPHENE DERIVATIVES | SULT1A1, SULT1E1, SULT2A1 | CA2 1619/4885CYP1A2 107/4885CYP3A4 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.