Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.33 |
| ▸ | USP7 | Q93009 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | USP14 | P54578 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2009185 | 0.90 | CYP11B1 (0.39) | CYP11B2CYP11B1GSK3BNR3C1ALDH1A1 | |
| SCHEMBL2002221 | 0.90 | PGR (0.40) | PGRCYP11B2ARNR3C1 | |
| SCHEMBL2006973 | 0.78 | PGR (0.36) | PGRCYP11B2CYP11B1NR3C1 | |
| SCHEMBL2006324 | 0.76 | MAPT (0.37) | ALDH1A1MAPK1NPSR1HSD17B10 | |
| SCHEMBL2003406 | 0.75 | CYP11B1 (0.38) | CYP11B2CYP11B1NR3C1ALDH1A1 | |
| SCHEMBL2006894 | 0.74 | NR3C1 (0.38) | PGRCYP11B2CYP11B1NR3C1FGFR1 | |
| SCHEMBL2005406 | 0.73 | FFAR4 (0.38) | ALDH1A1NPSR1 | |
| SCHEMBL27778418 | 0.73 | SLC2A1 (0.42) | PGRUSP7NR3C1ALDH1A1MAPK1 | |
| SCHEMBL2005767 | 0.72 | ESRRA (0.36) | PGRCYP11B2CYP11B1NR3C1FGFR1 | |
| SCHEMBL2008360 | 0.72 | NR3C1 (0.35) | PGRCYP11B2CYP11B1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118068-A1 | INDAZOLES USED TO TREAT ESTROGEN RECEPTOR BETA MEDIATED DISORDERS | Glaxo Group Limited (GB) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008107455-A1 | INDAZOLES USED TO TREAT ESTROGEN RECEPTOR BETA MEDIATED DISORDERS | GLAXO GROUP LIMITED (GB) | 2008-09-12 | — | — | WO | disclosed |