Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.35 |
| ▸ | HTR2A | P28223 | 5/20 | 0.34 |
| ▸ | HTR2B | P41595 | 5/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178086 | 0.84 | ALDH1A1 (0.38) | HTR2CHTR2AHTR2BSLC6A2SLC6A4 | |
| SCHEMBL6178088 | 0.84 | ALDH1A1 (0.38) | HTR2CHTR2AHTR2BSLC6A2SLC6A4 | |
| SCHEMBL11114653 | 0.71 | SIGMAR1 (0.45) | HTR2CHTR2AALDH1A1HTR3EHTR3B | |
| SCHEMBL27769842 | 0.69 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3ALDH1A1HTT | |
| SCHEMBL1028438 | 0.68 | SLC6A2 (0.57) | HTR2CHTR2AHTR2BSLC6A2SLC6A4 | |
| SCHEMBL17884678 | 0.68 | SLC6A2 (0.57) | HTR2CHTR2AHTR2BSLC6A2SLC6A4 | |
| SCHEMBL17884836 | 0.68 | SLC6A2 (0.57) | HTR2CHTR2AHTR2BSLC6A2SLC6A4 | |
| SCHEMBL1505813 | 0.68 | LMNA (0.31) | HTTLMNA | |
| SCHEMBL2309048 | 0.68 | LMNA (0.31) | HTTLMNA | |
| SCHEMBL2456274 | 0.68 | LMNA (0.31) | HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041088-A1 | GLYCINE TRANSPORTER-1 INHIBITORS | Amgen Inc. (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008002583-A1 | GLYCINE TRANSPORTER-1 INHIBITORS | AMGEN INC. (US) | 2008-01-03 | — | — | WO | disclosed |