Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.40 |
| ▸ | SCD | O00767 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433479 | 0.84 | AOC3 (0.48) | HRH3KDM4EGAAPARP1PARP2 | |
| SCHEMBL64557 | 0.83 | NPC1 (0.47) | HRH3KDM4EPARP1DCTPP1SCD | |
| SCHEMBL937146 | 0.81 | DRD4 (0.50) | PRKAA2ALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL25719351 | 0.81 | PARP1 (0.44) | PARP1PARP2SCDPRKAA2 | |
| SCHEMBL24620129 | 0.80 | BPTF (0.54) | KDM4EGAASCDALDH1A1HPGD | |
| SCHEMBL27634139 | 0.79 | HTR1A (0.52) | DCTPP1SCDMEN1KMT2A | |
| SCHEMBL938002 | 0.79 | LMNA (0.48) | GAADCTPP1SCD | |
| SCHEMBL20021209 | 0.79 | CYP1A2 (0.53) | PARP1ALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL937485 | 0.78 | SCD (0.48) | DCTPP1SCD | |
| SCHEMBL27654401 | 0.78 | MAPT (0.46) | KDM4ESCDALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |