Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 10/20 | 0.57 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442126 | 0.90 | P2RX7 (0.55) | P2RX7POLBKDM4EALDH1A1LMNA | |
| SCHEMBL4442516 | 0.87 | P2RX7 (0.76) | P2RX7 | |
| SCHEMBL4441990 | 0.87 | P2RX7 (0.76) | P2RX7 | |
| SCHEMBL4443575 | 0.87 | P2RX7 (0.55) | P2RX7POLBKDM4EALDH1A1LMNA | |
| SCHEMBL4440132 | 0.86 | P2RX7 (0.61) | P2RX7 | |
| SCHEMBL27776437 | 0.83 | P2RX7 (0.63) | P2RX7NLRP3CNR2POLBLMNA | |
| SCHEMBL306808 | 0.83 | P2RX7 (0.63) | P2RX7NLRP3CNR2POLBLMNA | |
| SCHEMBL305747 | 0.83 | P2RX7 (0.58) | P2RX7NLRP3CNR2POLBLMNA | |
| SCHEMBL305748 | 0.83 | P2RX7 (0.58) | P2RX7NLRP3CNR2POLBLMNA | |
| SCHEMBL306152 | 0.83 | P2RX7 (0.58) | P2RX7NLRP3CNR2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124562-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2009-12-02 | — | — | EP | claimed |
| WO-2008112205-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2008-09-18 | — | — | WO | claimed |