Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7958219 | 0.78 | LMNA (0.47) | TDP1ALDH1A1LMNAHPGDTP53 | |
| SCHEMBL19946014 | 0.76 | ESR1 (0.60) | HIF1ATDP1ALDH1A1LMNAHPGD | |
| SCHEMBL27961334 | 0.76 | CYP2A6 (0.38) | MAPK1ALDH1A1HPGDMAPTCYP2A6 | |
| SCHEMBL3984010 | 0.76 | CHRNA7 (0.44) | TDP1ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL1323137 | 0.75 | TSHR (0.52) | TSHRALDH1A1L3MBTL1LMNAHPGD | |
| SCHEMBL10159567 | 0.75 | TSHR (0.52) | TSHRALDH1A1L3MBTL1LMNAHPGD | |
| SCHEMBL7825067 | 0.75 | ALDH1A1 (0.60) | TSHRHIF1AMAPK1TDP1ALDH1A1 | |
| SCHEMBL5071435 | 0.75 | ALDH1A1 (0.46) | TSHRHIF1AMAPK1TDP1ALDH1A1 | |
| SCHEMBL4563754 | 0.74 | GAA (0.44) | TSHRTDP1ALDH1A1L3MBTL1LMNA | |
| SCHEMBL25341159 | 0.74 | ALDH1A1 (0.39) | TSHRHIF1AMAPK1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110885319-B | Sulfonamide compounds as sodium channel blockers and uses thereof | 成都康弘药业集团股份有限公司 | 2022-08-12 | — | — | CN | disclosed |
| WO-2020052509-A1 | SULFONAMIDE COMPOUND SERVING AS SODIUM CHANNEL BLOCKER AND USES THEREOF | 成都康弘药业集团股份有限公司 | 2020-03-19 | — | — | WO | disclosed |
| CN-110885319-A | Sulfonamide compounds as sodium channel blockers and uses thereof | 成都康弘药业集团股份有限公司 | 2020-03-17 | — | — | CN | disclosed |
| CN-102548963-A | Novel N-substituted-pyrrolidines as inhibitors of MDM2-p53 interactions | HOFFMANN LA ROCHE | 2012-07-04 | — | — | CN | disclosed |
| WO-2012034954-A1 | SUBSTITUTED HEXAHYDROPYRROLO [1, 2 - C] IMIDAZOLONES USEFUL AS MDM2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-22 | — | — | WO | disclosed |
| US-20120065210-A1 | SUBSTITUTED HEXAHYDROPYRROLO[1,2-C]IMIDAZOLONES | CHU XIN-JIE (US) | 2012-03-15 | — | — | US | disclosed |
| US-4369322-A | WITH CYANOGEN CHLORIDE | DEGUSSA AG (DE) | 1983-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065210-A1 | SUBSTITUTED HEXAHYDROPYRROLO[1,2-C]IMIDAZOLONES | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, DPYD, HK1 | TSHR 2088/4885HIF1A 2429/4885MAPK1 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.