Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 1/20 | 0.42 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946272 | 0.84 | GNAI3 (0.52) | GNAI3GNAO1GNAI1CHRM5ADRA2C | |
| SCHEMBL2761795 | 0.82 | GNAI3 (0.50) | GNAI3GNAO1GNAI1CHRM5ADRA2C | |
| SCHEMBL2761704 | 0.82 | GNAI3 (0.50) | GNAI3GNAO1GNAI1CHRM5ADRA2C | |
| SCHEMBL23448772 | 0.80 | GNAI3 (0.59) | GNAI3GNAO1GNAI1SPHK1HRH3 | |
| Hydrochloric Acid SCHEMBL913928 | 0.80 | GNAI3 (0.53) | GNAI3GNAO1GNAI1CHRM5ADRA2C | |
| Hydrochloric Acid SCHEMBL914047 | 0.80 | GNAI3 (0.53) | GNAI3GNAO1GNAI1CHRM5ADRA2C | |
| SCHEMBL6944001 | 0.78 | GNAI3 (0.57) | GNAI3GNAO1GNAI1SPHK1TSHR | |
| SCHEMBL23273615 | 0.78 | KEAP1 (0.40) | GNAI3GNAO1GNAI1LMNATSHR | |
| SCHEMBL277482 | 0.76 | LMNA (0.47) | CHRM5ADRA2CLMNATSHRHRH3 | |
| SCHEMBL7122468 | 0.75 | HRH3 (0.41) | CHRM5ADRA2CHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136807-A1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE DERIVATIVES FOR TREATING TUBERCULOSIS | Glaxo Group Limited (GB) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008125594-A1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE DERIVATIVES FOR TREATING TUBERCULOSIS | GLAXO GROUP LIMITED (GB) | 2008-10-23 | — | — | WO | disclosed |