Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8102006 | 0.87 | GRIN1 (0.55) | GRIN1GRIN2AKDM5BCDC7PIM1 | |
| SCHEMBL8092328 | 0.86 | KDM5B (0.47) | GRIN1GRIN2AKDM5BCDC7PIM1 | |
| SCHEMBL8101399 | 0.86 | NPC1 (0.52) | GRIN1GRIN2APIK3CDKDM4EALDH1A1 | |
| SCHEMBL1537159 | 0.85 | KDM4E (0.55) | GRIN1GRIN2AKDM4EALDH1A1POLB | |
| SCHEMBL8108081 | 0.83 | GAA (0.50) | GRIN1GRIN2AKDM5BPIK3CDKDM4E | |
| SCHEMBL8106228 | 0.81 | RAD51 (0.54) | GRIN1GRIN2AKDM4EALDH1A1POLB | |
| SCHEMBL8106086 | 0.81 | MEN1 (0.54) | KDM4EALDH1A1HPGDRXFP1NPC1 | |
| SCHEMBL8102003 | 0.81 | PKM (0.44) | GRIN1GRIN2AKDM4EALDH1A1POLB | |
| SCHEMBL8101357 | 0.79 | HTT (0.49) | KDM5BKDM4EALDH1A1HTTPKM | |
| SCHEMBL18495774 | 0.77 | MAPT (0.48) | KDM5BCDC7PIM1GSK3BHIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132207-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008118454-A2 | DERIVATIVES OF QUINOLINE OR BENZOPYRAZINE AND THEIR USES FOR THE TREATMENT OF (INTER ALIA) INFLAMMATORY DISEASES, AUTOIMMUNE DISEASES OR VARIOUS KINDS OF CANCER | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |
| US-6071930-A | FOR INHIBITION OF MITOSIS OR TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-06-06 | — | — | US | disclosed |
| US-5994367-A | PREVENT CELL MITOSIS; ANTICARCINOGENIC AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-11-30 | — | — | US | disclosed |