SCHEMBL8092328

SCHEMBL8092328

Cc1cc(C)n2c(=O)cc(-c3cccc(F)c3)nc2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM5B Q9UGL1 1/20 0.47
CDC7 O00311 1/20 0.44
PIM1 P11309 1/20 0.44
GSK3B P49841 1/20 0.44
HIPK2 Q9H2X6 1/20 0.44
CLK4 Q9HAZ1 1/20 0.44
PDE10A Q9Y233 1/20 0.43
KMT2A Q03164 4/20 0.40
RAD52 P43351 1/20 0.40
MEN1 O00255 3/20 0.40
NPC1 O15118 3/20 0.40
RAB9A P51151 3/20 0.40
CASP3 P42574 1/20 0.40
SENP8 Q96LD8 1/20 0.40
SENP7 Q9BQF6 1/20 0.40
SENP6 Q9GZR1 1/20 0.40
KDM4E B2RXH2 5/20 0.39
MAPT P10636 3/20 0.39
POLB P06746 1/20 0.39
ALDH1A1 P00352 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8099799 0.88 NPC1 (0.51) KMT2AMEN1NPC1RAB9ACASP3
SCHEMBL4440840 0.86 GRIN1 (0.51) KDM5BCDC7PIM1GSK3BHIPK2
SCHEMBL8100020 0.85 RAD51 (0.49) KDM5BCDC7PIM1GSK3BHIPK2
SCHEMBL8102012 0.84 KDM5B (0.48) KDM5BPIM1GSK3BHIPK2CLK4
SCHEMBL8101679 0.83 MEN1 (0.53) PDE10AKMT2AMEN1NPC1RAB9A
SCHEMBL8108277 0.80 RAD51 (0.55) KMT2AMEN1NPC1RAB9ACASP3
SCHEMBL8106201 0.80 CTRC (0.45) KMT2AMEN1NPC1RAB9ACASP3
SCHEMBL8108178 0.77 NPC1 (0.47) KDM5BPDE10ANPC1RAB9AMAPT
SCHEMBL8100231 0.76 GRIN1 (0.49) KDM5BCDC7PIM1GSK3BHIPK2
SCHEMBL18495774 0.75 MAPT (0.48) KDM5BCDC7PIM1GSK3BHIPK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6136434-A COMPRISING A METAL WIRE AND AT LEAST ONE COLORED COATING LAYER AROUND THE WIRE, WHEREIN THE COLORED LAYER IS PROVIDED BY A COATING COMPOSITION COMPRISING A SYNTHETIC RESIN, AN ORGANIC SOLVENT AND AN INORGANIC PIGMENT Tai-- I Electric Wire & Cable Co., Ltd. (TW) 2000-10-24 US claimed
US-6136434-A COMPRISING A METAL WIRE AND AT LEAST ONE COLORED COATING LAYER AROUND THE WIRE, WHEREIN THE COLORED LAYER IS PROVIDED BY A COATING COMPOSITION COMPRISING A SYNTHETIC RESIN, AN ORGANIC SOLVENT AND AN INORGANIC PIGMENT Tai-- I Electric Wire & Cable Co., Ltd. (TW) 2000-10-24 US disclosed
US-6071930-A FOR INHIBITION OF MITOSIS OR TUMOR GROWTH THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2000-06-06 US disclosed
US-5994367-A PREVENT CELL MITOSIS; ANTICARCINOGENIC AGENTS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1999-11-30 US disclosed