Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CTRC | Q99895 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | RAD51 | Q06609 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAC1 | P63000 | 2/20 | 0.39 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1537159 | 0.85 | KDM4E (0.55) | PKMCYP1A2HTTRXFP1RAD51 | |
| SCHEMBL8106201 | 0.85 | CTRC (0.45) | CTRCCYP1A2RAD51KDM4ENPC1 | |
| SCHEMBL8106228 | 0.84 | RAD51 (0.54) | PKMCYP1A2HTTRXFP1RAD51 | |
| SCHEMBL8101399 | 0.83 | NPC1 (0.52) | PKMCYP1A2HTTRXFP1RAD51 | |
| SCHEMBL7921851 | 0.82 | PKM (0.49) | PKMKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL8101357 | 0.82 | HTT (0.49) | PKMHTTRXFP1RAD51KDM4E | |
| SCHEMBL8102006 | 0.82 | GRIN1 (0.55) | PKMCYP1A2HTTRXFP1RAD51 | |
| SCHEMBL8106086 | 0.81 | MEN1 (0.54) | RXFP1KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL8108081 | 0.81 | GAA (0.50) | PKMCYP1A2HTTRXFP1RAD51 | |
| SCHEMBL4440840 | 0.81 | GRIN1 (0.51) | PKMCYP1A2HTTRXFP1RAD51 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071930-A | FOR INHIBITION OF MITOSIS OR TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-06-06 | — | — | US | disclosed |
| US-5994367-A | PREVENT CELL MITOSIS; ANTICARCINOGENIC AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-11-30 | — | — | US | disclosed |