Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | FADS1 | O60427 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13167962 | 0.81 | FADS1 (0.38) | MDM2TP53FADS1CNR1CNR2 | |
| SCHEMBL3580371 | 0.78 | TRPM4 (0.37) | MDM2FADS1CNR1CNR2MAPKAPK2 | |
| SCHEMBL3593156 | 0.76 | HPGD (0.34) | MDM2TP53MAPTFADS1HPGD | |
| SCHEMBL14899252 | 0.76 | FADS1 (0.36) | MDM2FADS1CNR1CNR2SMN1; SMN2 | |
| SCHEMBL3587420 | 0.74 | ALDH1A1 (0.35) | MDM2TP53MAPTFADS1 | |
| SCHEMBL3587518 | 0.74 | FADS1 (0.36) | MDM2FADS1CNR1CNR2 | |
| SCHEMBL3598426 | 0.73 | MAOA (0.39) | CCR1CCR2 | |
| SCHEMBL3592419 | 0.73 | ALDH1A1 (0.34) | MDM2FADS1MAPKAPK2 | |
| SCHEMBL3599941 | 0.72 | MAPT (0.39) | MDM2MAPTMAPKAPK2SMN1; SMN2 | |
| SCHEMBL15182326 | 0.71 | LMNA (0.34) | FADS1CNR1CNR2MAPKAPK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121598-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2009-11-25 | — | — | EP | claimed |
| WO-2008076754-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2008-06-26 | — | — | WO | claimed |
| EP-2121598-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008076754-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2008-06-26 | — | — | WO | disclosed |