Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508031 | 0.92 | HSD17B10 (0.39) | POLBCETPLMNATSHRHSD17B10 | |
| SCHEMBL4442467 | 0.91 | MAPT (0.38) | DYRK1ACLK4DYRK1BLMNASMN1; SMN2 | |
| SCHEMBL7507160 | 0.90 | TDP1 (0.44) | POLBRXFP1MCL1LMNASMN1; SMN2 | |
| SCHEMBL7507750 | 0.88 | L3MBTL1 (0.35) | ALDH1A1TDP1L3MBTL1KCNH2 | |
| SCHEMBL7509782 | 0.86 | TDP1 (0.41) | RXFP1TDP1L3MBTL1KCNH2 | |
| SCHEMBL7507831 | 0.86 | SMN1; SMN2 (0.36) | RXFP1LMNASMN1; SMN2MAPT | |
| SCHEMBL7516627 | 0.86 | DRD2 (0.39) | RXFP1SMN1; SMN2ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL4442879 | 0.85 | HSD17B10 (0.38) | POLBRXFP1SMN1; SMN2USP2ALDH1A1 | |
| SCHEMBL7508005 | 0.85 | HTR1A (0.33) | LMNASMN1; SMN2TDP1L3MBTL1PPARD | |
| SCHEMBL7509955 | 0.85 | PDGFRB (0.39) | RXFP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |