Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.83 |
| ▸ | DRD3 | P35462 | 10/20 | 0.83 |
| ▸ | DRD4 | P21917 | 9/20 | 0.83 |
| ▸ | HTR2A | P28223 | 6/20 | 0.57 |
| ▸ | DRD1 | P21728 | 3/20 | 0.57 |
| ▸ | HTR1A | P08908 | 5/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3608995 | 0.92 | DRD2 (0.70) | DRD2DRD3DRD4HTR2ADRD1 | |
| SCHEMBL3610324 | 0.91 | DRD2 (1.00) | DRD2DRD3DRD4HTR2ADRD1 | |
| SCHEMBL3608700 | 0.89 | DRD3 (0.88) | DRD2DRD3DRD4HTR2ADRD1 | |
| SCHEMBL4445019 | 0.75 | DRD3 (0.60) | DRD2DRD3DRD4HTR2ADRD1 | |
| SCHEMBL4564124 | 0.73 | DRD2 (0.60) | DRD2DRD3DRD4HTR2ADRD1 | |
| SCHEMBL4443269 | 0.73 | DRD2 (0.76) | DRD2DRD3DRD4HTR2ADRD1 | |
| SCHEMBL3605911 | 0.73 | DRD2 (1.00) | DRD2DRD3DRD4HTR2ADRD1 | |
| SCHEMBL3614783 | 0.73 | DRD2 (1.00) | DRD2DRD3DRD4HTR2ADRD1 | |
| SCHEMBL3615525 | 0.73 | DRD2 (1.00) | DRD2DRD3DRD4HTR2ADRD1 | |
| SCHEMBL4450992 | 0.73 | ALDH1A1 (0.57) | DRD2DRD3DRD4HTR2ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137185-A2 | INDOLIZINES AND AZA-ANALOG DERIVATIVES THEREOF AS CNS ACTIVE COMPOUNDS | Gmeiner, Dr. Peter (DE) | 2009-12-30 | — | — | EP | claimed |
| WO-2008113559-A2 | INDOLIZINES AND AZA-ANALOG DERIVATIVES THEREOF AS CNS ACTIVE COMPOUNDS | SCHWARZ PHARMA AG (DE) | 2008-09-25 | — | — | WO | claimed |