Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.32 |
| ▸ | HTR2C | P28335 | 4/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3670912 | 0.77 | HPGDS (0.32) | MTNR1AMTNR1BHTR2CHPGDS | |
| SCHEMBL3333076 | 0.77 | CHRM1 (0.42) | MTNR1AMTNR1BHTR2CRIPK1CHRM1 | |
| SCHEMBL3328929 | 0.77 | CHRM1 (0.42) | MTNR1AMTNR1BHTR2CRIPK1CHRM1 | |
| SCHEMBL22168968 | 0.75 | DRD2 (0.40) | CHRM1 | |
| SCHEMBL4442971 | 0.75 | DRD2 (0.40) | CHRM1 | |
| SCHEMBL19470005 | 0.74 | RIPK1 (0.33) | MTNR1AMTNR1BHTR2CRIPK1CHRM1 | |
| SCHEMBL3327481 | 0.74 | HTR2C (0.34) | MTNR1AMTNR1BHTR2CRIPK1 | |
| SCHEMBL19470010 | 0.72 | CYP2D6 (0.34) | MTNR1AMTNR1BHTR2CCHRM1 | |
| SCHEMBL19470009 | 0.72 | CYP2D6 (0.34) | MTNR1AMTNR1BHTR2CCHRM1 | |
| SCHEMBL17515246 | 0.69 | HPGDS (0.33) | MTNR1AMTNR1BHTR2CHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137196-A1 | TRICYCLIC NITROGEN CONTAINING COMPOUNDS AS ANTIBACTERIAL AGENTS | Glaxo Group Limited (GB) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008128942-A1 | TRICYCLIC NITROGEN CONTAINING COMPOUNDS AS ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |