Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17515246 | 0.86 | HPGDS (0.33) | HPGDSHTR2CMTNR1AMTNR1B | |
| SCHEMBL4442191 | 0.77 | MTNR1A (0.32) | HPGDSHTR2CMTNR1AMTNR1B | |
| SCHEMBL5744761 | 0.66 | KCNH2 (0.34) | HPGDSMTNR1AMTNR1B | |
| SCHEMBL5307877 | 0.65 | KCNH2 (0.47) | MTNR1AMTNR1B | |
| SCHEMBL5015196 | 0.63 | KCNH2 (0.34) | — | |
| SCHEMBL23900328 | 0.62 | GAA (0.41) | HTR2CMTNR1AMTNR1B | |
| SCHEMBL29014262 | 0.62 | GAA (0.41) | HTR2CMTNR1AMTNR1B | |
| SCHEMBL30314386 | 0.62 | GAA (0.41) | HTR2CMTNR1AMTNR1B | |
| SCHEMBL23887518 | 0.62 | CRBN (0.42) | HTR2CMTNR1AMTNR1B | |
| SCHEMBL23887515 | 0.62 | CRBN (0.42) | HTR2CMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238138-A1 | TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS | Glaxo Group Limited (GB) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009087153-A1 | TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | disclosed |