Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | RAD52 | P43351 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21435085 | 0.87 | KDM4E (0.45) | KMT2APDE3BPDE3ATDP1RAD52 | |
| SCHEMBL4440621 | 0.85 | KMT2A (0.45) | KMT2APDE3BPDE3ATDP1KDM4E | |
| SCHEMBL4435275 | 0.77 | NT5E (0.44) | KMT2AKDM4EALDH1A1CYP1A2MAPT | |
| SCHEMBL4437045 | 0.75 | L3MBTL1 (0.40) | KMT2AP2RX7KDM4EALDH1A1CYP1A2 | |
| SCHEMBL4437069 | 0.74 | PDE10A (0.47) | KMT2ATDP1KDM4EALDH1A1LMNA | |
| SCHEMBL6983102 | 0.71 | KDM4E (0.46) | KMT2ARAD52KDM4EALDH1A1CYP1A2 | |
| SCHEMBL11599658 | 0.71 | KDM4E (0.47) | KMT2APDE3BPDE3ATDP1KDM4E | |
| SCHEMBL6175786 | 0.71 | P2RX7 (0.40) | KMT2AP2RX7TDP1RAD52KDM4E | |
| SCHEMBL5526828 | 0.71 | KDM4E (0.43) | KMT2ATDP1KDM4EALDH1A1LMNA | |
| SCHEMBL10251704 | 0.71 | KMT2A (0.51) | KMT2AKDM4EALDH1A1MEN1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |