Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441914 | 0.81 | SMN1; SMN2 (0.51) | PDE10AALDH1A1GAAMAPTKDM4E | |
| SCHEMBL4433755 | 0.81 | LMNA (0.44) | PDE10AALDH1A1GAAMAPTKDM4E | |
| SCHEMBL31123821 | 0.77 | ALDH1A1 (0.42) | PDE10AALDH1A1GAAMAPTKDM4E | |
| SCHEMBL22743951 | 0.77 | ALDH1A1 (0.42) | PDE10AALDH1A1GAAMAPTKDM4E | |
| SCHEMBL4440621 | 0.75 | KMT2A (0.45) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL4442200 | 0.74 | KMT2A (0.40) | ALDH1A1GAAMAPTKDM4ERAB9A | |
| SCHEMBL15319751 | 0.73 | PDE10A (0.44) | PDE10AALDH1A1GAAMAPTKDM4E | |
| SCHEMBL18668983 | 0.72 | CASP3 (0.51) | ALDH1A1GAAMAPTKDM4ERAB9A | |
| SCHEMBL4437043 | 0.71 | ALDH1A1 (0.42) | PDE10AALDH1A1GAAMAPTKDM4E | |
| SCHEMBL248919 | 0.71 | LMNA (0.42) | ALDH1A1GAAMAPTKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |