Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.30 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
| ▸ | XIAP | P98170 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL358067 | 0.73 | RAB9A (0.42) | MAPK1LMNASMN1; SMN2 | |
| SCHEMBL8313115 | 0.72 | HTR2A (0.43) | DHODH | |
| SCHEMBL4430653 | 0.70 | — | — | |
| SCHEMBL4436785 | 0.70 | — | — | |
| SCHEMBL4441709 | 0.69 | PDE10A (0.41) | — | |
| SCHEMBL4436859 | 0.69 | NR1I2 (0.33) | — | |
| SCHEMBL15065498 | 0.69 | CA1 (0.37) | MAPK1SMN1; SMN2 | |
| SCHEMBL4441393 | 0.66 | CA2 (0.37) | MAPK1LMNA | |
| SCHEMBL29056314 | 0.64 | IDO1 (0.52) | DHODHMAPK1SMN1; SMN2 | |
| SCHEMBL31650754 | 0.64 | HTT (0.50) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618981-B2 | to treat cellular proliferative diseases, hyperplasias, solid tumor, cardiac hypertrophy, immune disorders and inflammation; modulators of one or more mitotic kinesins; N-(2-(2-dimethylamino-acetylamino)-1-{4-[8-(1-hydroxy-ethyl)-imidazo[1,2-a]pyridin-2-yl]-benzyl}-ethyl)-3-chloro-4-isopropoxy-benzamide | CYTOKINETICS, INC. (US) | 2009-11-17 | — | — | US | claimed |