Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1856429 | 0.85 | POLB (0.51) | POLBALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4571000 | 0.85 | POLB (0.48) | POLBALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1856417 | 0.78 | MMP2 (0.54) | ALDH1A1CYP1A2CYP2C9CYP2C19MMP1 | |
| SCHEMBL1857442 | 0.77 | CPA3 (0.49) | ALDH1A1CYP1A2CYP2C9CYP2C19MMP2 | |
| SCHEMBL1859707 | 0.75 | POLB (0.53) | POLBALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8039484 | 0.72 | HTR6 (0.58) | HDAC8HDAC2HDAC6MMP1MMP2 | |
| SCHEMBL1861591 | 0.72 | HDAC2 (0.52) | POLBALDH1A1CYP1A2L3MBTL1AKR1C3 | |
| SCHEMBL1857365 | 0.71 | CYP1A2 (0.61) | CYP1A2 | |
| SCHEMBL1857400 | 0.71 | POLB (0.49) | POLBALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL18713706 | 0.71 | HDAC4 (0.50) | L3MBTL1LMNASMN1; SMN2HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080722-A2 | CARBOXYLIC DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | CRYSTAX PHARMACEUTICALS, S.L. (ES) | 2009-07-02 | — | — | WO | disclosed |