Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL385345 | 1.00 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2DPP7POLB | |
| SCHEMBL13254845 | 1.00 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2DPP7POLB | |
| SCHEMBL10757334 | 0.98 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2DPP7POLB | |
| SCHEMBL10752905 | 0.96 | DPP7 (0.51) | NPC1RAB9ASMN1; SMN2DPP7POLB | |
| SCHEMBL10591026 | 0.96 | DPP7 (0.51) | NPC1RAB9ASMN1; SMN2DPP7POLB | |
| SCHEMBL14740663 | 0.93 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2DPP7POLB | |
| SCHEMBL2824467 | 0.91 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2DPP7POLB | |
| SCHEMBL1419834 | 0.87 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2DPP7POLB | |
| SCHEMBL3169796 | 0.87 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2DPP7POLB | |
| SCHEMBL6214888 | 0.86 | DPP7 (0.39) | NPC1RAB9ASMN1; SMN2DPP7POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10017481-B2 | Conformationally constrained, fully synthetic macrocyclic compounds | POLYPHOR AG (CH) | 2018-07-10 | — | — | US | claimed |
| US-9512139-B2 | Conformationally constrained, fully synthetic macrocyclic compounds | POLYPHOR AG (CH) | 2016-12-06 | — | — | US | claimed |
| US-20150051183-A1 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | POLYPHOR AG (CH) | 2015-02-19 | — | — | US | claimed |
| US-20120270881-A1 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | POLYPHOR AG (CH) | 2012-10-25 | — | — | US | claimed |
| EP-4170347-A1 | GASTRIC INHIBITORY PEPTIDE RECEPTOR LIGANDS | 3B Pharmaceuticals GmbH (DE) | 2023-04-26 | — | — | EP | disclosed |
| US-10017481-B2 | Conformationally constrained, fully synthetic macrocyclic compounds | POLYPHOR AG (CH) | 2018-07-10 | — | — | US | disclosed |
| US-20170369523-A1 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS THAT ARE LIGANDS FOR G-PROTEIN-COUPLED RECEPTORS (GPCRS) AND ARE MODULATORS OF TRANSCRIPTION FACTORS AND COACTIVATORS | POLYPHOR AG (CH) | 2017-12-28 | — | — | US | disclosed |
| US-9284352-B2 | Beta-hairpin peptidomimetics having CXCR4 antagonizing activity | POLYPHOR AG (CH) | 2016-03-15 | — | — | US | disclosed |
| EP-2531204-B1 | TEMPLATE - FIXED PEPTIDOMIMETICS WITH CXCR7 MODULATING ACTIVITY | POLYPHOR AG (CH) | 2016-02-03 | — | — | EP | disclosed |
| US-20150051183-A1 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | POLYPHOR AG (CH) | 2015-02-19 | — | — | US | disclosed |
| US-8754038-B2 | Template-fixed peptidomimetics with CCR10 antagonistic activity | POLYPHOR AG (CH) | 2014-06-17 | — | — | US | disclosed |
| US-8716242-B2 | β-hairpin peptidomimetics | POLYPHOR AG (CH) | 2014-05-06 | — | — | US | disclosed |
| US-20120283196-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2012-11-08 | — | — | US | disclosed |
| EP-1937710-B1 | KININ B1 RECEPTOR PEPTIDE AGONISTS AND USES THEREOF | SOCPRA SCIENCES SANTE ET HUMAINES S E C (CA) | 2012-10-17 | — | — | EP | disclosed |
| EP-2501715-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CCR10 ANTAGONISTIC ACTIVTY | Polyphor Ag (CH) | 2012-09-26 | — | — | EP | disclosed |
| US-20120129774-A1 | KININ B1 RECEPTOR PEPTIDE AGONISTS AND USES THEREOF | UNIVERSITE DE SHERBROOKE (CA) | 2012-05-24 | — | — | US | disclosed |
| US-8076453-B2 | Kinin B1 receptor peptide agonists and uses thereof | Societe De Commercialisation Des Produits De La Recheche Appliquee-Socpra-Science Sante Et Humaines S.E.C. (CA) | 2011-12-13 | — | — | US | disclosed |
| US-20090054347-A1 | KININ B1 RECEPTOR PEPTIDE AGONISTS AND USES THEREOF | UNIVERSITE DE SHERBROOKE (CA) | 2009-02-26 | — | — | US | disclosed |
| EP-1937710-A1 | KININ B1 RECEPTOR PEPTIDE AGONISTS AND USES THEREOF | Université de Sherbrooke (CA) | 2008-07-02 | — | — | EP | disclosed |
| WO-2006128293-A1 | KININ B1 RECEPTOR PEPTIDE AGONISTS AND USES THEREOF | UNIVERSITé DE SHERBROOKE (CA) | 2006-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283196-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | CXCL12, CXCR4, CXCR1 | NPC1 3598/4885RAB9A 2613/4885SMN1; SMN2 618/4885 |
| US-10017481-B2 | Conformationally constrained, fully synthetic macrocyclic compounds | CTSE, CTSB, CTSS | NPC1 3288/4885RAB9A 2677/4885SMN1; SMN2 4312/4885 |
| US-20170369523-A1 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS THAT ARE LIGANDS FOR G-PROTEIN-COUPLED RECEPTORS (GPCRS) AND ARE MODULATORS OF TRANSCRIPTION FACTORS AND COACTIVATORS | NCOA1, NCOA2, NCOR1 | NPC1 2518/4885RAB9A 4520/4885SMN1; SMN2 1876/4885 |
| US-20120270881-A1 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | KCNB1, KCNAB1, KCNMB1 | NPC1 2470/4885RAB9A 1575/4885SMN1; SMN2 2606/4885 |
| US-20150051183-A1 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | CTSE, CTSB, CTSS | NPC1 3288/4885RAB9A 2677/4885SMN1; SMN2 4312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.