Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 3/20 | 0.55 |
| ▸ | PTPRC | P08575 | 3/20 | 0.41 |
| ▸ | S100A4 | P26447 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5886292 | 0.76 | PTPRC (0.56) | CES1PTPRCS100A4HIF1AMEN1 | |
| SCHEMBL8598895 | 0.72 | PTPRC (0.56) | CES1PTPRCS100A4HIF1AMEN1 | |
| SCHEMBL15442560 | 0.72 | PTPRC (0.55) | CES1PTPRCS100A4HIF1AMEN1 | |
| SCHEMBL380656 | 0.72 | CES1 (1.00) | CES1PTPRCHIF1AMEN1KMT2A | |
| SCHEMBL29370560 | 0.72 | PTPRC (0.55) | CES1PTPRCS100A4HIF1AMEN1 | |
| SCHEMBL7213583 | 0.71 | CES1 (0.72) | CES1PTPRCHIF1AMEN1KMT2A | |
| SCHEMBL87570 | 0.70 | CES1 (0.70) | CES1PTPRCHIF1AMEN1KMT2A | |
| SCHEMBL9122070 | 0.68 | HIF1A (0.53) | PTPRCS100A4HIF1AMEN1KMT2A | |
| SCHEMBL7106993 | 0.68 | PTPRC (0.55) | CES1PTPRCS100A4HIF1AMEN1 | |
| SCHEMBL31268201 | 0.68 | ALDH1A1 (0.63) | CES1PTPRCS100A4HIF1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1755574-A4 | PTEN INHIBITORS | SEMAFORE PHARMACEUTICALS INC (US) | 2009-05-13 | — | — | EP | disclosed |
| US-20070203098-A1 | Pten Inhibitors | SEMAFORE PHARMACEUTICALS, INC. (US) | 2007-08-30 | — | — | US | disclosed |
| EP-1755574-A2 | PTEN INHIBITORS | Semafore Pharmaceuticals, Inc. (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005097119-A2 | PTEN INHIBITORS | SEMAFORE PHARMACEUTICALS, INC. (US) | 2005-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203098-A1 | Pten Inhibitors | PTEN, MTMR1, PTPRJ | CES1 1635/4885PTPRC 12/4885S100A4 4203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.